Phytochemical And Acute Toxicity Effect Of The Root And Leaf Ethanolic Extract Of African Mahogany (Khaya Grandifoliola) On Albino-Mice Infected With Plasmodium Berghei Berghei

Abstract

The study investigated the phytochemical and acute toxicity effect of the ethanolic extracts of the root and leaf ethanolic extract of African Mahogany (Khaya Grandifoliola) on albino-mice infected with plasmodium berghei berghei. 30 Swiss adult albino mice of 6 groups of n=5 each was used for the study. phytochemical screening of the plant parts was carried out, and acute toxicity test of mice infected with Plasmodium berghei berghei at various doses of (250mg/kg, 500mg/kg, & 1000mg/kg). The results revealed that khaya grandifoliola contains alkaloids, tannin, cyanogenic glycoside, flavonoid, steroid, and saponin. Quantitatively the leaf and the root reavelaed alkaloids to be (2.81 and 1.80 %) , tannin (3.19%) and 2.55%), cyanogenic glycoside (0.13 and 0.08%), flavonoid (4.50 and 4.11%), steroid (3.74 and 2.18%), and saponin (1.42 and 1.38%) varying quantities. The acute toxicity test revealed no mortality after seven days in the different doses of the plant extracts. Conclusively Khaya Grandifoliola can be used for the treatment of malaria without any toxicity.